Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

76 questions · 80 findings · 41 reviews · Headline outcomes only

No studies found 7 · 8.8%GRADE not reported 6 · 7.5%Very low 15 · 18.8%Low 24 · 30%Moderate 19 · 23.8%High 9 · 11.3%

LABA/LAMA vs LABA plus inhaled corticosteroid (ICS)

All‐cause death · stable COPD

Long‐acting muscarinic antagonist (LAMA) plus long‐acting… probably leads to higher all‐cause death compared with LABA plus inhaled corticosteroid (ICS) (moderate certainty).

1 finding from 1 review

Rotarix vs placebo

All‐cause death · children

Rotarix showed no clear difference in all‐cause death compared with placebo (moderate certainty).

3 findings from 1 review

RotaTeq vs placebo

All‐cause death · children

RotaTeq showed no clear difference in all‐cause death compared with placebo (low certainty).

3 findings from 1 review