Question · asked by 1 review

RotaTeq vs placebo: All‐cause death

RotaTeq showed no clear difference in all‐cause death compared with placebo (low certainty).

What each review found

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FindingEffectStudiesGRADE certainty
RotaTeq vs placebo
All‐cause death · children
RotaTeq showed no clear difference in all‐cause death compared with placebo (low certainty).
Vaccines for preventing rotavirus diarrhoea: vaccines in use (2021) · Cochrane Headline outcomes only
RR 1.24 [0.69, 2.22]6 studies · 72654 participantsLow
RotaTeq vs placebo
All‐cause death · children
It is very uncertain whether rotaTeq changes all‐cause death compared with placebo (very low certainty).
Vaccines for preventing rotavirus diarrhoea: vaccines in use (2021) · Cochrane Headline outcomes only
RR 0.33 [0.01, 8.18]2 studies · 4088 participantsVery low
RotaTeq vs placebo
All‐cause death · children
RotaTeq showed no clear difference in all‐cause death compared with placebo (moderate certainty).
Vaccines for preventing rotavirus diarrhoea: vaccines in use (2021) · Cochrane Headline outcomes only
RR 0.91 [0.68, 1.23]3 studies · 7706 participantsModerate

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Vaccines for preventing rotavirus diarrhoea: vaccines in use
2021 · Cochrane Headline outcomes only
Not reportedlist not extracted yetNot assessed

Studies behind the findings

None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.

How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.