Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,337 questions · 1,354 findings · 566 reviews

No studies found 307 · 22.7%GRADE not reported 81 · 6%Very low 424 · 31.3%Low 310 · 22.9%Moderate 189 · 14%High 43 · 3.2%

Indacaterol vs long‐acting beta2‐agonist alone

Serious adverse events Adverse events · patients with chronic obstructive pulmonary disease

Indacaterol showed no clear difference in serious adverse events Adverse events compared with twice‐daily long‐acting beta2‐agonists (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events ‐ not measured · patients with acute gout

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Serious Adverse Events ‐ not reported · patients with shoulder pain

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs placebo

Serious adverse events(up to 6 months) · children and young people with JIA

Methotrexate showed no clear difference in serious adverse events(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Serious adverse events at up to day 28 · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care showed no clear difference in serious adverse events at up to day 28 compared with standard care (plus/minus placebo) (low certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events within 6 months · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

It is very uncertain whether casirivimab/imdevimab changes serious adverse events within 6 months compared with placebo (very low certainty).

1 finding from 1 review

TACE followed by 3‐DCRT vs chemoembolisation

Non‐serious adverse events: leukopenia · primary hepatocellular carcinoma

It is very uncertain whether TACE followed by 3‐DCRT changes non‐serious adverse events: leukopenia compared with TACE (very low certainty).

1 finding from 1 review

Two doses of HPV vaccine with longer interval vs two doses of HPV vaccine with shorter interval

Serious adverse events at up to 5‐year · 9‐ to 14‐year‐old females and males

It is very uncertain whether two doses of HPV vaccine with longer interval changes serious adverse events at up to 5‐year compared with two doses of HPV vaccine with shorter interval (very low certainty).

1 finding from 1 review

Two doses of HPV vaccine vs three doses of HPV vaccine

Serious adverse events at up to 5‐year · 9‐ to 15‐year‐old females

It is very uncertain whether two doses of HPV vaccine changes serious adverse events at up to 5‐year compared with three doses of HPV vaccine (very low certainty).

1 finding from 1 review