NSAIDs vs placebo
- Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes onlyno estimate extracted3 studies · 93 participantsVery low
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It is very uncertain whether the intervention changes adverse events Length of (very low certainty).
It is very uncertain whether summary of findings: General medication review changes adverse events Length of compared with usual care (very low certainty).
Larger atraumatic needles probably leads to lower adverse events: backache compared with smaller atraumatic needles (moderate certainty).
Traumatic needles showed no clear difference in adverse events: backache compared with atraumatic needles (moderate certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
Growth factors showed no clear difference in serious adverse events ( compared with placebo or no therapy (moderate certainty).
It is very uncertain whether ranolazine (monotherapy) changes adverse events incidence compared with placebo (very low certainty).
Ranolazine (add‐on therapy) probably leads to higher adverse events incidence compared with placebo (moderate certainty).
Airway bypass stents showed no clear difference in adverse events at end of compared with control (moderate certainty).
Endobronchial coils leads to higher adverse events at end of compared with control (high certainty).
Endobronchial valves leads to higher adverse events at end of compared with control (high certainty).
Intrabronchial valves leads to higher adverse events at end of compared with control (high certainty).