Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Retzius‐sparing RALP vs standard RALP

Serious adverse events · men (ages > 18 years) with clinically localized prostate cancer

It is very uncertain whether retzius‐sparing RALP changes serious adverse events compared with standard RALP (very low certainty).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Not applicable (single-arm safety outcome)

Serious adverse events · Children and older adults treated with SDF for carious lesions

No serious adverse events (e.g., allergic reactions or toxicity) were reported for SDF across the reviews (ungraded).

1 finding from 1 review

Lithium vs ARIPIPRAZOLE

Adverse event: tremor · acute mania

Lithium showed no clear difference in adverse events: tremor compared with aripiprazole (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.45 [0.65, 3.24]
    1 study · 313 participants
    Moderate