Findings

What do systematic reviews say?

4,918 questions · 5,537 findings · 1,803 reviews

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No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Adalimumab vs active comparators

Adverse events · People with quiescent Crohn's disease (ileocolic resection)

The review found no eligible studies for this question.

1 finding from 1 review

Adalimumab for maintenance of remission in Crohn's disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Adalimumab vs placebo

Adverse events · Participants with Crohn's disease in remission

Adalimumab showed no clear difference in adverse events compared with placebo (high certainty).

1 finding from 1 review

Adalimumab for maintenance of remission in Crohn's disease 2020 · Cochrane Headline outcomes only
RR 1.01 [0.94, 1.09]
4 studies · 1012 participants
High

Magnesium sulphate vs hypertonic saline

Adverse events · children up to 12 months old with acute bronchiolitis

The review found no eligible studies for this question.

1 finding from 1 review

Magnesium sulphate for treating acute bronchiolitis in children up to two years of age 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Magnesium sulphate or magnesium sulphate + salbutamol vs salbutamol

Adverse events · children from 1 month to 24 months old with acute bronchiolitis

1 finding from 1 review

Magnesium sulphate for treating acute bronchiolitis in children up to two years of age 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 56 participants
GRADE not reported

Magnesium sulphate + epinephrine vs no treatment or normal saline + epinephrine

Adverse events · children up to 12 months old with acute bronchiolitis

The review found no eligible studies for this question.

1 finding from 1 review

Magnesium sulphate for treating acute bronchiolitis in children up to two years of age 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Magnesium sulphate vs placebo

Adverse events · children up to 18 months old with acute bronchiolitis

1 finding from 1 review

Magnesium sulphate for treating acute bronchiolitis in children up to two years of age 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 160 participants
GRADE not reported

Intervention not reported

Adverse events · people with severe frostbite injuries

1 finding from 1 review

Interventions for frostbite injuries 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Adverse events · people with severe frostbite injuries

1 finding from 1 review

Interventions for frostbite injuries 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Adverse events · people with severe frostbite injuries

1 finding from 1 review

Interventions for frostbite injuries 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Motor neuroprosthesis vs another assistive technology device

Adverse events · promoting recovery of function after stroke

Motor neuroprosthesis may leads to higher adverse events compared with another assistive technology device (low certainty).

1 finding from 1 review

Motor neuroprosthesis for promoting recovery of function after stroke 2020 · Cochrane Headline outcomes only
RR 1.48 [1.11, 1.97]
4 studies · 829 participants
Low

Paracervical vs intravenous diazepam/pethidine analgesia

Adverse events · women with persistent or prolonged retention of placenta

The review found no eligible studies for this question.

1 finding from 1 review

Anaesthesia/analgesia for manual removal of retained placenta 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Serlopitant 0.25 mg vs placebo

Adverse events · chronic pruritus of unknown origin

It is very uncertain whether serlopitant 0.25 mg changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Interventions for chronic pruritus of unknown origin 2020 · Cochrane Headline outcomes only
RR 1.29 [0.75, 2.24]
1 study · 127 participants
Very low

Serlopitant 5 mg vs placebo

Adverse events · chronic pruritus of unknown origin

It is very uncertain whether serlopitant 5 mg changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Interventions for chronic pruritus of unknown origin 2020 · Cochrane Headline outcomes only
RR 1.48 [0.87, 2.5]
1 study · 127 participants
Very low

Serlopitant 1 mg vs placebo

Adverse events · chronic pruritus of unknown origin

It is very uncertain whether serlopitant 1 mg changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Interventions for chronic pruritus of unknown origin 2020 · Cochrane Headline outcomes only
RR 1.45 [0.86, 2.47]
1 study · 128 participants
Very low

Fenretinide vs placebo

Adverse events · adults with GA due to AMD

1 finding from 1 review

Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 246 participants
Low

Emixustat vs placebo

Adverse events · adults with GA due to AMD

1 finding from 1 review

Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to… 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 575 participants
Moderate

Resilience interventions vs controls

Adverse events · healthcare students, including students in training for health professions delivering direct medical care (e.g. medical students, nursing…

1 finding from 1 review

Psychological interventions to foster resilience in healthcare students 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 566 participants
Very low

Doxycycline + SRP vs SRP

Adverse events · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included study has not reported adverse events
Studies not reported
No studies found

Clindamycin + SRP vs Metronidazole + SRP

Adverse events · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included study has not reported adverse events
Studies not reported
No studies found

Azithromycin + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether azithromycin + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
1 study reported diarrhoea, headache or dizziness, metallic taste, and general unwellness by 4 participants from the intervention group and 3 from the control group. In 1 study none of the participants reported any…
2 studies · 110 participants
Very low