Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Acetazolamide vs placebo

Adverse events: Paresthesias‐ Follow‐ up: From arrival to 24 hours later · participants at risk of high altitude illness

Acetazolamide may leads to higher adverse events: Paresthesias‐ Follow‐ up: From arrival to 24 hours… compared with placebo (low certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs QUETIAPINE

Adverse events: Specific ‐ prolactin‐related · patients with schizophrenia

RISPERIDONE DEPOT may leads to higher adverse events: Specific ‐ prolactin‐related Reported by… compared with ORAL QUETIAPINE (low certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs ARIPIPRAZOLE

Adverse events: General ‐ serious Unclear how these events were reported · patients with schizophrenia

It is very uncertain whether RISPERIDONE DEPOT changes adverse events: General ‐ serious Unclear how these events were… compared with ORAL ARIPIPRAZOLE (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Non‐serious adverse events Maximum · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes adverse events considered non‐serious (penicillin versus… compared with other antibiotics (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo

Major adverse events (eyelid ptosis, eyelid sensory disorder, strabismus) · glabellar lines

Summary of Findings Table ‐ AbobotulinumtoxinA 50U showed no clear difference in major adverse events (eyelid ptosis, eyelid sensory disorder,… compared with placebo (moderate certainty).

1 finding from 1 review

Intrathecal injected nusinersen vs sham

Adverse events attributable to treatment · infants with SMA and 2 SMN2 copies

Intrathecal injected nusinersen showed no clear difference in adverse events attributable to treatment Measured as adverse events… compared with sham procedure (moderate certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to treatment failure due to adverse events All participants Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine leads to lower time to treatment failure due to adverse events All participants… compared with phenytoin (primary outcomes) (high certainty).

1 finding from 1 review

Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo

Number of participants experiencing any serious adverse events · people with Alzheimer's disease

Vitamin E (capsules 2000 IU/day in two divided doses) showed no clear difference in adverse events Number of participants reporting ≥ 1 serious adverse… compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of participants withdrawn due to adverse events (at 6 to 10 weeks) · Adults with ADHD

The intervention showed no clear difference in number of participants withdrawn due to adverse events (at 6 to 10… (low certainty).

1 finding from 1 review