Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Donepezil 23 mg/day vs donepezil 10 mg/day

Risk for at least one adverse event per patient · people with Alzheimer's disease

Donepezil 23 mg/day probably leads to higher incidence of adverse events (at least one adverse event by 24 weeks) compared with donepezil 10 mg/day (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs donepezil 5 mg/day

Risk for at least one adverse event per patient · people with Alzheimer's disease

Donepezil 10 mg/day probably leads to higher incidence of adverse events (at least one adverse event by 24 weeks) compared with donepezil 5 mg/day (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs placebo

Risk for at least one adverse event per patient · people with severe Alzheimer's disease

Donepezil 10 mg/day probably leads to higher incidence of adverse events (at least one adverse event by 24 weeks) compared with placebo (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs placebo

Risk for at least one adverse event per patient · people with Alzheimer's disease

Donepezil 10 mg/day probably leads to higher incidence of adverse events (at least one adverse event by 26 weeks) compared with placebo (moderate certainty).

1 finding from 1 review

Enteral vs enteral and parenteral nutrition

Adverse events: sepsis (as reported by study authors at end of study · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

The review found no eligible studies for this question.

1 finding from 1 review

Enteral vs parenteral nutrition

Adverse events: sepsis (as reported by study authors at end of study · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

Enteral may leads to lower adverse events: sepsis (as reported by study authors at end of study compared with parenteral nutrition (low certainty).

1 finding from 1 review

Oestrogen tablets vs other regimens

Adverse events (total adverse events) (oestrogen cream vs non‐hormonal lubricant gel) · postmenopausal women with vaginal atrophy

Oestrogen tablets showed no clear difference in adverse events (total adverse events) (oestrogen tablets vs placebo) compared with other regimens (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events None of the included studies evaluated adverse events · patients with acute low back pain

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events None of the included studies evaluated adverse events · patients with acute LBP

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events None of the included studies evaluated adverse events · patients with acute low back pain

The review found no eligible studies for this question.

1 finding from 1 review

Rivastigmine vs placebo

Risk for at least one adverse event per patient · Apathy in people with mild‐to‐moderate Alzheimer's disease

Rivastigmine probably leads to higher incidence of adverse events (at least one adverse event by 26 weeks) compared with placebo (moderate certainty).

1 finding from 1 review

PERPHENAZINE vs antipsychotics

Adverse events: extrapyramidal adverse effects ‐ dystonia ‐ short term · patients with schizophrenia

It is very uncertain whether PERPHENAZINE changes adverse events: extrapyramidal adverse effects dystonia ‐ short term compared with ANY ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

Perazine vs placebo

Adverse effects – leaving the study early due to adverse effects – overall tolerability – total · patients with schizophrenia
1 finding from 1 review
  • Perazine for schizophrenia 2014 · Cochrane Headline outcomes only
    no estimate extracted
    0 studies · 0 participants
    GRADE not reported

Peginterferon alpha‐2a vs peginterferon alpha‐2b

Discontinuation of medication due to adverse events · people with chronic hepatitis C

Peginterferon alpha‐2a showed no clear difference in adverse events leading to treatment discontinuation Number of events compared with peginterferon alpha‐2b (low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Adverse events considered non‐serious (penicillin versus doxycycline) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes adverse events considered non‐serious (penicillin versus doxycycline) compared with other antibiotics (very low certainty).

1 finding from 1 review

Recombinant zoster vaccine vs placebo

Participants with adverse events ‐ any local symptom Clinical criteria · healthy older adults aged ≥ 60 years

Recombinant zoster vaccine probably leads to higher participants with adverse events ‐ any local symptomClinical criteria compared with placebo (moderate certainty).

1 finding from 1 review