Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Levetiracetam vs placebo

Withdrawals due to adverse events · adults with SAnD

It is very uncertain whether comparison 3: anticonvulsant levetiracetam changes dropouts due to adverse events (acute phase) compared with placebo (very low certainty).

1 finding from 1 review

Antipsychotics vs placebo

Withdrawals due to adverse events · adults with SAnD

It is very uncertain whether comparison 4: antipsychotics changes dropouts due to adverse events (acute phase) compared with placebo (very low certainty).

1 finding from 1 review

Benzodiazepines vs placebo

Withdrawals due to adverse events · adults with SAnD

It is very uncertain whether comparison 5: benzodiazepines changes dropouts due to adverse events (acute phase) compared with placebo (very low certainty).

1 finding from 1 review

Methadone vs morphine

Adverse events: appetite, thirst, somnolence · people with cancer pain
1 finding from 1 review

Rituximab (B cell) + steroid vs steroids

Treatment adverse events: UTI/pyelonephritis · kidney transplant recipients: first rejection episode

Rituximab (B cell) + steroid probably leads to higher treatment adverse events: UTI/pyelonephritis compared with steroid alone (moderate certainty).

1 finding from 1 review