Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Higher BP target (< 150‐160/95‐105 mmHg) vs lower BP target (< 140/90 mmHg)

Serious adverse events: cardiovascular events · older adults with primary hypertension

Higher BP target (< 150‐160/95‐105 mmHg) showed no clear difference in cardiovascular serious adverse events compared with lower BP target (< 140/90 mmHg) (low certainty).

1 finding from 1 review

Bortezomib vs no bortezomib

Adverse Events: Peripheral Neuropathy · All patients with a diagnosis of multiple myeloma

Bortezomib probably leads to higher adverse Events: Peripheral Neuropathy compared with no bortezomib (moderate certainty).

1 finding from 1 review

Trapeziectomy with ligament reconstruction and tendon interposition (T and LRTI) vs trapeziectomy and ligament reconstruction (T and LR)

Adverse events Complications reported · Patients with thumb (trapeziometacarpal joint) osteoarthritis

Trapeziectomy with ligament reconstruction and tendon interposition… showed no clear difference in adverse events Complications reported compared with trapeziectomy and ligament reconstruction (T and LR) (low certainty).

1 finding from 1 review