Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Omega‐3 vs placebo

Diarrhoea · adults and children with cystic fibrosis

It is very uncertain whether summary of findings: omega‐3 fatty acid supplementation changes adverse events: diarrhoea compared with placebo (very low certainty).

1 finding from 1 review

Rituximab/cyclosporin/prednisolone vs cyclosporin/prednisolone

Adverse effects of antibiotics (skin rash) · idiopathic steroid‐resistant nephrotic syndrome in children

It is very uncertain whether rituximab/cyclosporin/prednisolone changes adverse events: skin rash compared with cyclosporin/prednisolone (very low certainty).

1 finding from 1 review

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery

Adverse events (moderate) · people with single or solitary brain metastasis

It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (moderate) compared with stereotactic radiosurgery (very low certainty).

1 finding from 1 review

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery plus WBRT

Adverse events (moderate) · people with single or solitary brain metastasis

It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (moderate) compared with stereotactic radiosurgery plus WBRT (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events ‐ myopathy · people with cardiovascular disease or at high risk of cardiovascular disease

It is very uncertain whether the intervention changes adverse events ‐ myopathy (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events at 1 year' · participants with glaucoma or ocular hypertension

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Unexpected adverse events · children with critical illness

It is very uncertain whether the intervention changes unexpected adverse events (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events (vomiting) · children aged less than 6 months with acute diarrhoea

The intervention probably leads to higher adverse events (vomiting) (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events (vomiting) · children with persistent diarrhoea

It is very uncertain whether the intervention changes adverse events (vomiting) (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events (vomiting) · children with acute diarrhoea

The intervention probably leads to higher adverse events (vomiting) (moderate certainty).

1 finding from 1 review