Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,949 questions · 1,994 findings · 636 reviews

No studies found 504 · 25.3%GRADE not reported 340 · 17.1%Very low 477 · 23.9%Low 390 · 19.6%Moderate 241 · 12.1%High 42 · 2.1%

Intervention not reported

Adverse effects · Patients with unknown duration of mechanical neck pain

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse effects · Patients with subacute/chronic mechanical neck pain

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse effects · Various (pregnant women; daily smokers aged 16 and older; university students; children aged 5‐13)
1 finding from 1 review

Intervention not reported

Adverse effects ( · Patients with type 2 diabetes mellitus
1 finding from 1 review

Clofazimine (100 mg daily for 30 days, then 100 mg every other day) vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Pentoxifylline vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
  • Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
    60 days (plus 60-day follow-up)
    Patients receiving pentoxifylline reported more adverse events than those in the placebo group but this was not statistically significant (69% reported adverse effects: dizziness, headaches, stomach upset, increased…
    1 study · 26 participants
    GRADE not reported

Colchicine (0.5 mg per day for 3 months) vs prednisolone

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review