Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

117 questions · 119 findings · 20 reviews · Skin

No studies found 28 · 23.5%GRADE not reported 2 · 1.7%Very low 26 · 21.8%Low 21 · 17.6%Moderate 37 · 31.1%High 5 · 4.2%

Tacrolimus 0.1% vs pimecrolimus 1%

Adverse effects ‐ 6 weeks · people with atopic dermatitis

It is very uncertain whether tacrolimus 0.1% changes adverse effects ‐ 6 weeks compared with pimecrolimus 1% (very low certainty).

1 finding from 1 review

Topical clindamycin vs placebo

Adverse effects (non‐serious) · participants with hidradenitis suppurativa

Topical clindamycin showed no clear difference in adverse effects (non‐serious) compared with placebo (moderate certainty).

1 finding from 1 review

NB‐UVB vs medium‐dose UVA‐1 phototherapy (50 J/cm²)

Adverse events associated with treatment · children and adults with active morphea (circumscribed morphea, linear scleroderma (with trunk/limb variant and head variant), generalised…

Narrowband UVB phototherapy may leads to lower primary outcome: Adverse effects compared with medium‐dose UVA‐1 phototherapy (50 J/cm²) (low certainty).

1 finding from 1 review

NB‐UVB vs low‐dose UVA‐1 phototherapy (20 J/cm²)

Adverse events associated with treatment · children and adults with active morphea (circumscribed morphea, linear scleroderma (with trunk/limb variant and head variant), generalised…

Narrowband UVB phototherapy may leads to lower primary outcome: Adverse effects compared with low‐dose UVA‐1 phototherapy (20 J/cm²) (low certainty).

1 finding from 1 review

Oral methotrexate and oral prednisone vs prednisone or placebo

Adverse events associated with treatment · children and adolescents with active morphea (linear scleroderma, generalised morphea and mixed subtype: linear and circumscribed).

Oral methotrexate and oral prednisone showed no clear difference in primary outcome: Adverse effects compared with placebo and oral prednisone (low certainty).

1 finding from 1 review

Medium‐dose UVA‐1 phototherapy (50 J/cm²) vs low‐dose UVA‐1 phototherapy (20 J/cm²)

Adverse events associated with treatment · children and adults with active morphea (circumscribed morphea, linear scleroderma (with trunk/limb variant and head variant), generalised…

Medium‐dose UVA‐1 phototherapy (50 J/cm²) showed no clear difference in primary outcome: Adverse effects compared with low‐dose UVA‐1 phototherapy (20 J/cm²) (low certainty).

1 finding from 1 review