What do systematic reviews say?

Topical triamcinolone acetonide vs Topical tacrolimus

Topical triamcinolone acetonide may leads to lower adverse effects compared with topical tacrolimus (low certainty).

• Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes

  3-8 weeks
  RR 0.47 [0.22, 0.99]
  2 studies · 58 participants
  Low

The wand (computer-controlled LA delivery system) vs Sleeper One (electronic LA delivery system)

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  During LA (injection is the intervention)
  Adverse effects: included studies did not report on this outcome
  Studies not reported
  No studies found

Chlorhexidine (mouthrinse or gel), as part of oral hygiene care vs placebo or usual care

• Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
  Adverse effects: information from 2 studies; one stated there were none, the other reported mild reversible irritation of the oral mucosa; very low certainty. There was a lack of evidence about adverse effects.
  2 studies
  Very low

Electrical counter-stimulation device (DentalVibe) vs Conventional treatment (no stimulation)

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  During LA
  Adverse effects: included studies did not report on this outcome
  Studies not reported
  No studies found

Bone removal technique (chisel / piezoelectric / ultrasonic) vs Conventional mechanical caries removal (standard drill; handpiece with a bur)

The review found no eligible studies for this question.

• Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes

  up to 30 days
  no estimate extracted
  Studies not reported
  No studies found

Counter-stimulation and distraction (combined) vs Conventional treatment

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  During LA
  Adverse effects: included studies did not report on this outcome
  Studies not reported
  No studies found

Irrigation technique A vs Irrigation technique B

The review found no eligible studies for this question.

• Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes

  up to 30 days
  no estimate extracted
  Studies not reported
  No studies found

Topical clobetasol propionate vs Topical tacrolimus

It is very uncertain whether topical clobetasol propionate changes adverse effects compared with topical tacrolimus (very low certainty).

• Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes

  3-8 weeks
  RR 0.05 [0.00, 0.83]
  2 studies · 100 participants
  Very low

Topical triamcinolone acetonide vs Topical ciclosporin

Topical triamcinolone acetonide led to lower adverse effects compared with topical ciclosporin; GRADE not reported.

• Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes

  end of treatment
  RR 0.15 [0.05, 0.49]
  1 study · 139 participants
  GRADE not reported

Hypnosis vs Conventional treatment

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  Immediately before or during LA
  Adverse effects: included studies did not report on this outcome
  Studies not reported
  No studies found

Video modelling acclimatisation vs Acclimatisation in clinic (tell-show-do)

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  In advance of LA
  Adverse effects: included studies did not report on this outcome
  Studies not reported
  No studies found

The wand (computer-controlled LA delivery system) vs other local anaesthetic

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  During LA (injection is the intervention)
  Adverse effects: included studies did not report on this outcome
  Studies not reported
  No studies found

Dexamethasone + nystatin + curcumin (adjunctive) vs Dexamethasone + nystatin + placebo

• Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
  Amirchaghmaghi 2016: no adverse effects recorded in either group (low-certainty)
  1 study
  Low

Counter-stimulation or distraction vs Conventional treatment

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  Immediately before or during LA
  Adverse effects: included studies did not report on this outcome
  Studies not reported
  No studies found

Pneumococcal conjugate vaccine vs control vaccine

The review found no eligible studies for this question.

• Pneumococcal conjugate vaccines for preventing acute otitis media in children 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Any prophylaxis vs no prophylaxis

It is very uncertain whether any prophylaxis changes adverse effects compared with no prophylaxis (very low certainty).

• Interventions for preventing ophthalmia neonatorum 2020 · Cochrane Headline outcomes only
  OR 0.93
  1993 participants
  Very low

Ketogenic diet (KD) vs other KDs

• Ketogenic diets for drug‐resistant epilepsy 2020 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 286 participants
  Very low

Ketogenic diet (KD) vs other KDs

• Ketogenic diets for drug‐resistant epilepsy 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 80 participants
  Very low

Ketogenic diet (KD) vs usual care

• Ketogenic diets for drug‐resistant epilepsy 2020 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 425 participants
  Low

Ketogenic diet (KD) vs usual care

• Ketogenic diets for drug‐resistant epilepsy 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 141 participants
  Very low