What do systematic reviews say?

Paracervical vs placebo

Paracervical probably leads to higher adverse effects ‐ Hypotension compared with placebo (moderate certainty).

• Paracervical local anaesthesia for cervical dilatation and uterine intervention 2013 · Cochrane Headline outcomes only
  RR 3.06 [1.21, 7.78]
  2 studies · 171 participants
  Moderate

Red blood cell transfusion vs no red blood cell transfusion

The review found no eligible studies for this question.

• Red cell transfusion for the management of upper gastrointestinal haemorrhage 2010 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hawley removable retainer vs Clear plastic removable retainer

The review found no eligible studies for this question.

• Retention procedures for stabilising tooth position after treatment with orthodontic braces 2023 · Cochrane All outcomes

  12 months · lower arch
  Not measured
  0 studies
  No studies found

Full-time wear of removable retainer (any type) vs Part-time wear of removable retainer (any type)

The review found no eligible studies for this question.

• Retention procedures for stabilising tooth position after treatment with orthodontic braces 2023 · Cochrane All outcomes

  12 months · lower arch
  Not measured
  0 studies
  No studies found

Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment

• Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
  No serious adverse effects were reported across five studies that assessed harms (Katchooi 2018; Lombardo 2018; Pavlin 2015; Reiss 2020; Taha 2020).
  5 studies
  GRADE not reported

Inhaled tobramycin (TNS) (28 days) vs TNS (56 days)

• Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 77 participants
  Very low

Oral ciprofloxacin and inhaled colistin vs no treatment

• Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 26 participants
  Very low

Summary of findings table ‐ Delayed antibiotics vs immediate antibiotics

• Immediate versus delayed versus no antibiotics for respiratory infections 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1302 participants
  Low

Interventions (ibuprofen, tolfenamic acid, aspirin, tranexamic acid) vs placebo or active comparators (paracetamol, tranexamic acid)

The review found no eligible studies for this question.

• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

The review found no eligible studies for this question.

• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antibiotic prophylaxis before dental procedure vs placebo or no prophylaxis

The review found no eligible studies for this question.

• Antibiotic prophylaxis for preventing bacterial endocarditis following dental procedures 2022 · Cochrane All outcomes
  Adverse effects of antibiotics | No data reported | 248 (1 study) | - | -
  0 studies
  No studies found

Phacoemulsification vs phacoemulsification plus viscogonioplasty

The review found no eligible studies for this question.

• Lens extraction for chronic angle‐closure glaucoma 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pedometer intervention vs alternative physical activity intervention

The review found no eligible studies for this question.

• Workplace pedometer interventions for increasing physical activity 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Physical activity interventions with a caregiver component vs interventions without a caregiver component

The review found no eligible studies for this question.

• Caregiver involvement in interventions for improving children's dietary intake and physical activity behaviors 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dietary behavior change interventions with a caregiver component vs interventions without a caregiver component

The review found no eligible studies for this question.

• Caregiver involvement in interventions for improving children's dietary intake and physical activity behaviors 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topiramate vs placebo

Topiramate probably leads to higher adverse effects ‐ paraesthesia compared with placebo (moderate certainty).

• Topiramate add‐on therapy for drug‐resistant focal epilepsy 2019 · Cochrane Headline outcomes only
  RR 3.65 [1.58, 8.39]
  7 studies · 1071 participants
  Moderate

Combined interventions vs usual care

Combined interventions showed no clear difference in adverse effects: reinfarctions compared with usual care (moderate certainty).

• Interventions to support return to work for people with coronary heart disease 2019 · Cochrane Headline outcomes only
  RR 0.56 [0.23, 1.43]
  3 studies · 265 participants
  Moderate

Parent training vs control

The review found no eligible studies for this question.

• Parent training programmes for managing infantile colic 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Buspirone vs placebo

The review found no eligible studies for this question.

• Miscellaneous treatments for antipsychotic‐induced tardive dyskinesia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found