What do systematic reviews say?

Bee propolis (one 500 mg capsule per day) vs placebo

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  6 months (minimum)
  Propolis was associated with low rates of minimal side effects.
  1 study · 19 participants
  GRADE not reported

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  90 days
  No differences in adverse events were reported.
  1 study · 50 participants
  GRADE not reported

Individualised homeopathic medicine (two doses over 24 hours) vs placebo

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  6 days
  No participant needed to discontinue treatment due to adverse events.
  1 study · 100 participants
  GRADE not reported

Sodium hypochlorite 5% vs Sodium hypochlorite 5% with proteolytic enzyme

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Colchicine (0.5 mg three times per day) vs Clofazimine (100 mg daily for 30 days, then 100 mg every other day)

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  6 months
  Clofazimine was associated with an increase in cutaneous adverse effects (Fisher's exact test P=0.015), easily controlled; there was a greater percentage of treatment interruptions in the colchicine group due to…
  1 study · 46 participants
  GRADE not reported

Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Sodium hypochlorite 1%

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Sodium hypochlorite 1% with chlorhexidine 2% final rinse vs Sodium hypochlorite 1% with normal saline final rinse

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Massage for mechanical neck disorders 2012 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Massage for mechanical neck disorders 2012 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Massage for mechanical neck disorders 2012 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Adenosine‐diphosphate (ADP) receptor antagonists for the prevention of cardiovascular disease in type 2 diabetes… 2012 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Urokinase (any strength) vs placebo

It is very uncertain whether urokinase (any strength) changes adverse effects compared with placebo (very low certainty).

• Interventions for restoring patency of occluded central venous catheter lumens 2012 · Cochrane Headline outcomes only
  RR 2.88 [0.38, 21.93]
  1 study · 72 participants
  Very low

Intervention not reported

• Mobile phone messaging for preventive health care 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1705 participants
  Moderate

Interactive computer intervention vs usual care

The review found no eligible studies for this question.

• Interactive computer‐based interventions for weight loss or weight maintenance in overweight or obese people 2012 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Interactive computer intervention vs in‐person interventions

The review found no eligible studies for this question.

• Interactive computer‐based interventions for weight loss or weight maintenance in overweight or obese people 2012 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Zinc vs placebo

The review found no eligible studies for this question.

• Zinc supplementation for mental and motor development in children 2012 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Disc arthroplasty vs fusion

• Total disc replacement for chronic back pain in the presence of disc degeneration 2012 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Neurodynamic mobilisation vs no treatment

• Exercise and mobilisation interventions for carpal tunnel syndrome 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 14 participants
  Very low

Leukotriene receptor antagonist vs placebo

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  2 months
  The study reported equal drug-related adverse effects for those treated with montelukast and placebo.
  1 study · 40 participants
  GRADE not reported

Chlorhexidine 0.2% vs Normal saline

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found