What do systematic reviews say?

HP paint-on gel vs HP paint-on gel

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Tooth sensitivity in both groups with no evidence of a difference (Ziebolz 2008)
  1 study
  GRADE not reported

HP gel in tray vs placebo

The review found no eligible studies for this question.

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Not reported
  Studies not reported
  No studies found

HP mouthwash vs placebo

The review found no eligible studies for this question.

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Not reported
  Studies not reported
  No studies found

CP paint-on gel vs placebo

The review found no eligible studies for this question.

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Not reported
  Studies not reported
  No studies found

CP gel in tray vs placebo

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Main adverse events reported in majority of trials were mild and transient tooth sensitivity and oral irritation which occurred more in the intervention group compared to placebo
  3 studies
  GRADE not reported

HP strips vs HP gel in tray

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Tooth sensitivity and oral irritation mild and transient and did not differ between groups
  2 studies
  GRADE not reported

HP paint-on gel vs HP strips

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Adverse events mild; slightly higher tooth hypersensitivity and gingival irritation in strip group but no evidence of a difference
  2 studies
  GRADE not reported

SHMP chewing gum vs placebo

The review found no eligible studies for this question.

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Not reported
  Studies not reported
  No studies found

CP paint-on gel vs HP paint-on gel

The review found no eligible studies for this question.

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Not reported
  Studies not reported
  No studies found

CP paint-on gel vs CP paint-on gel

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Very mild tooth sensitivity in the 4x/day group; gingival and tooth sensitivity transient, none withdrew
  2 studies
  GRADE not reported

CP gel in tray vs CP gel in tray

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Higher concentrations of CP in tray led to more tooth sensitivity and gingival irritation; symptoms mild and transient; CP with desensitiser showed significantly less sensitivity
  4 studies
  GRADE not reported

HP strips vs CP gel in tray

• Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
  Results variable for tooth sensitivity and oral irritation, some favouring strip, some tray, some no difference
  7 studies
  GRADE not reported

Withdrawal of anticholinergic medication vs continuing anticholinergic medication

• Anticholinergic medication for antipsychotic‐induced tardive dyskinesia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Melatonin vs placebo or no treatment

• Miscellaneous treatments for antipsychotic‐induced tardive dyskinesia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 54 participants
  Low

Brief intervention vs no intervention or minimal intervention

• Effectiveness of brief alcohol interventions in primary care populations 2018 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 5 participants
  Very low

Public reporting of performance data vs no public reporting

The review found no eligible studies for this question.

• Impact of public release of performance data on the behaviour of healthcare consumers and providers 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hyperbaric oxygen vs air breathing

Hyperbaric oxygen leads to higher adverse effects compared with air breathing (high certainty).

• Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
  RR 2.05 [1.22, 3.46]
  3 studies · 456 participants
  High

Hyperbaric oxygen vs air breathing

Hyperbaric oxygen leads to higher adverse effects compared with air breathing (high certainty).

• Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
  RR 2.35 [1.66, 3.33]
  7 studies · 779 participants
  High

Hyperbaric oxygen vs air breathing to enhance the effectiveness of radiotherapy

Hyperbaric oxygen probably leads to higher adverse effects compared with air breathing to enhance the effectiveness of radiotherapy (moderate certainty).

• Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
  RR 2.64 [1.65, 4.23]
  4 studies · 323 participants
  Moderate

Educational intervention vs no educational intervention

The review found no eligible studies for this question.

• Vision screening for correctable visual acuity deficits in school‐age children and adolescents 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found