Cochrane · systematic review · CD000204
Anticholinergic medication for antipsychotic‐induced tardive dyskinesia
Bergman, H, Soares‐Weiser, K · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
18
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 14 · 77.8%Very low 4 · 22.2%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Anticholinergic medication compared with placebo for antipsychotic‐induced tardive dyskinesia
Population: patients with antipsychotic‐induced tardive dyskinesia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tardive dyskinesia: not improved to a clinically important extent Anticholinergic medication vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Tardive dyskinesia: deterioration of symptoms Anticholinergic medication vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Mental state Anticholinergic medication vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Adverse effect: any adverse effects Anticholinergic medication vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Acceptability of the treatment: leaving the study early Anticholinergic medication vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Social confidence, social inclusion, social networks, or personalised quality of life Anticholinergic medication vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Anticholinergic medication compared with other treatments for antipsychotic‐induced tardive dyskinesia
Population: chronic schizophrenia patients with antipsychotic‐induced tardive dyskinesia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tardive dyskinesia: Not improved to a clinically important extent Anticholinergic medication vs other treatments | RR 4.2 [1.4, 12.58] | 1 study · 20 participants | Very low Downgraded: risk of bias |
Tardive dyskinesia: deterioration of symptoms Anticholinergic medication vs other treatments | no estimate extracted | 0 studies · 0 participants | Ungraded |
Mental state Anticholinergic medication vs other treatments | no estimate extracted | 0 studies · 0 participants | Ungraded |
Adverse effect: any adverse effects Anticholinergic medication vs other treatments | RR 0.33 [0.02, 7.32] | 1 study · 20 participants | Very low Downgraded: risk of bias |
Acceptability of the treatment: leaving the study early Anticholinergic medication vs other treatments | RR 0.33 [0.02, 7.32] | 1 study · 20 participants | Very low Downgraded: risk of bias |
Social confidence, social inclusion, social networks, or personalised quality of life Anticholinergic medication vs other treatments | no estimate extracted | 0 studies · 0 participants | Ungraded |
Withdrawal of anticholinergic medication compared to continuing anticholinergic medication for antipsychotic‐induced tardive dyskinesia
Population: chronic schizophrenia patients with antipsychotic‐induced tardive dyskinesia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tardive dyskinesia: not improved to a clinically important extent Withdrawal of anticholinergic medication vs continuing anticholinergic medication | no estimate extracted | 0 studies · 0 participants | Ungraded |
Tardive dyskinesia: deterioration of symptoms Withdrawal of anticholinergic medication vs continuing anticholinergic medication | no estimate extracted | 0 studies · 0 participants | Ungraded |
Mental state Withdrawal of anticholinergic medication vs continuing anticholinergic medication | no estimate extracted | 0 studies · 0 participants | Ungraded |
Adverse effects Withdrawal of anticholinergic medication vs continuing anticholinergic medication | no estimate extracted | 0 studies · 0 participants | Ungraded |
Acceptability of the treatment: leaving the study early Withdrawal of anticholinergic medication vs continuing anticholinergic medication | RR 2.14 [0.11, 42.52] | 1 study · 10 participants | Very low Downgraded: risk of bias |
Social confidence, social inclusion, social networks, or personalised quality of life Withdrawal of anticholinergic medication vs continuing anticholinergic medication | no estimate extracted | 0 studies · 0 participants | Ungraded |