Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

11 questions · 11 findings · 7 reviews · Haematology

No studies found 1 · 9.1%GRADE not reported 0 · 0%Very low 1 · 9.1%Low 7 · 63.6%Moderate 2 · 18.2%High 0 · 0%

Intervention not reported

Admission to hospital or death up to day 45 · non‐hospitalised adults with mild COVID‐19

It is very uncertain whether the intervention changes admission to hospital or death up to day 45 (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs placebo or usual care

Admission to hospital or death within 28 days · outpatients withmild disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in admission to hospital or death within 28 days compared with placebo or standard care alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs standard plasma

Admission to hospital or death within 28 days · outpatients withmild disease

Summary of findings table ‐ Convalescent plasma probably leads to lower admission to hospital or death within 28 days compared with standard plasma (moderate certainty).

1 finding from 1 review

Azithromycin vs placebo or usual care

Admission to hospital or death within 28 days · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

Azithromycin showed no clear difference in admission to hospital or death within 28 days compared with placebo or standard of care alone (low certainty).

1 finding from 1 review

Fluvoxamine plus standard care vs placebo + standard care

All‐cause admission to hospital or death (before hospital admission) · symptomatic people with COVID‐19

Fluvoxamine plus standard care showed no clear difference in all‐cause admission to hospital or death (before hospital admission) compared with placebo plus standard care (low certainty).

1 finding from 1 review

Intervention not reported

Worsening of clinical status: admission to hospital or death within 28 days · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in worsening of clinical status: admission to hospital or death within… (low certainty).

1 finding from 1 review