Cochrane · systematic review · CD015391
Fluvoxamine for the treatment of COVID‐19
Nyirenda, JLZ, Sofroniou, M, Toews, I, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
4
No studies
3
Included studies
NR
No studies 3 · 42.9%Ungraded 0 · 0%Very low 2 · 28.6%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Fluvoxamine plus standard care compared to placebo plus standard care for outpatients with mild COVID‐19
Population: symptomatic people with COVID‐19
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality (at day 28) Fluvoxamine plus standard care vs placebo plus standard care | RR 0.69 [0.38, 1.27] | 2 studies · 1649 participants | Low Downgraded: imprecision |
All‐cause admission to hospital or death (before hospital admission) Fluvoxamine plus standard care vs placebo plus standard care | RR 0.55 [0.16, 1.89] | 2 studies · 1649 participants | Low Downgraded: imprecision |
Symptom resolution Fluvoxamine plus standard care vs placebo plus standard care | no estimate extracted | NR | No studies |
Quality of life (at longest Fluvoxamine plus standard care vs placebo plus standard care | no estimate extracted | NR | No studies |
Serious adverse events (during study period) Fluvoxamine plus standard care vs placebo plus standard care | RR 0.56 [0.15, 2.03] | 2 studies · 1649 participants | Very low Downgraded: risk of bias, imprecision |
Any adverse events (during study period) Fluvoxamine plus standard care vs placebo plus standard care | RR 1.06 [0.82, 1.37] | 2 studies · 1649 participants | Very low Downgraded: risk of bias, imprecision |
Suicide or suicide attempt (at longest Fluvoxamine plus standard care vs placebo plus standard care | no estimate extracted | NR | No studies |