Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

13 questions · 13 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 6 · 46.2%Very low 7 · 53.8%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Zuclopenthixol dihydrochloride vs chlorpromazine

Adverse effects: Clinically important general adverse effect (EPSEs) · schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes adverse effects: Clinically important general adverse effect (EPSEs) compared with chlorpromazine (very low certainty).

1 finding from 1 review

Zuclopenthixol dihydrochloride vs sulpiride

Adverse effects: Clinically important general adverse effect ‐ requiring hypnotics/sedatives · schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes adverse effects: Clinically important general adverse effect ‐… compared with sulpiride (very low certainty).

1 finding from 1 review

Zuclopenthixol dihydrochloride vs RISPERIDONE

Adverse effects: Clinically important general adverse effect ‐ short term (EPSEs requiring medication) · schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes adverse effects: Clinically important general adverse effect ‐ short… compared with risperidone (very low certainty).

1 finding from 1 review

Zuclopenthixol dihydrochloride vs OTHER ANTIPSYCHOTIC: f. PERPHENAZINE

Adverse effects: Clinically important general adverse effect (EPSEs requiring medication ‐ medium term) · schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes adverse effects: Clinically important general adverse effect (EPSEs… compared with perphenazine (very low certainty).

1 finding from 1 review

Zuclopenthixol dihydrochloride vs placebo

Adverse effects ‐ important extrapyramidal adverse effects · patients with schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes adverse effects: Clinically important general adverse effect… compared with placebo (very low certainty).

1 finding from 1 review

Zuclopenthixol dihydrochloride (Cis Z isomer) vs Zuclopenthixol (Cis Z/Trans E isomer)

Adverse effects: Clinically important general adverse effect (no data) · schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride (Cis Z isomer) changes adverse effects: Clinically important general adverse effect compared with zuclopenthixol (Cis Z/Trans E isomer) (very low certainty).

1 finding from 1 review