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What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 7 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 4 · 57.1%Moderate 1 · 14.3%High 0 · 0%

Methotrexate vs placebo

Withdrawals due to adverse events · children and young people with JIA

Methotrexate showed no clear difference in withdrawals due to adverse events (up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Withdrawals due to adverse events · psoriatic arthritis

Methotrexate showed no clear difference in withdrawals due to adverse events (WAEs) assessed by number of events compared with placebo (low certainty).

1 finding from 1 review

Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone

Withdrawals due to adverse events · children and young people with JIA

Oral methotrexate plus intra‐articular glucocorticoid showed no clear difference in withdrawals due to adverse events(12 months) compared with intra‐articular glucocorticoid alone (low certainty).

1 finding from 1 review