The event rate of intensive care delirium within 28 days. · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…
Haloperidol showed no clear difference in the event rate of intensive care delirium within 28 days. compared with placebo (moderate certainty).
1 finding from 1 review
In‐hospital mortality within 28 days. · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…
Haloperidol showed no clear difference in in‐hospital mortality within 28 days. compared with placebo (moderate certainty).
1 finding from 1 review
Number of delirium ‐ and coma‐free days (within 28 days) measured by CAM‐ICU or ICDSC · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…
1 finding from 1 review
Ventilator‐free days up to day 28 · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…
1 finding from 1 review
Duration of ICU stay · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…
1 finding from 1 review
Cognitive impairment · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…
1 finding from 1 review
Tranquilisation or asleep not asleep at 2 hours · patients with psychosis‐induced aggression or agitation
It is very uncertain whether HALOPERIDOL changes tranquillisation or asleep not asleep at 2 hours compared with PLACEBO/NIL (very low certainty).
1 finding from 1 review
Global outcome ‐ need for benzodiazepine during 24 hours · patients with psychosis‐induced aggression or agitation
It is very uncertain whether HALOPERIDOL changes global outcomes: need for benzodiazepine 2 compared with OTHER ANTIPSYCHOTIC: a. ARIPIPRAZOLE (very low certainty).
1 finding from 1 review
Specific behaviour ‐ threat or injury to self or others ‐ not reported · patients with psychosis‐induced aggression or agitation
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Global outcome: general ‐ no improvement · patients with psychosis‐induced aggression or agitation
It is very uncertain whether HALOPERIDOL changes global outcome: general ‐ no overall improvement compared with COMBINATIONS: a. HALOPERIDOL + LEVOMEPROMAZINE (very low certainty).
1 finding from 1 review
Adverse effect: any serious, specific ‐ not reported · patients with psychosis‐induced aggression or agitation
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Economic outcomes ‐ not measured · patients with psychosis‐induced aggression or agitation
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Tranquilisation or asleep ‐ not asleep by 3 hours · patients with psychosis‐induced aggression or agitation
It is very uncertain whether HALOPERIDOL changes tranquillisation or asleep ‐ not asleep by 3 hours compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).
1 finding from 1 review
Repeated need for rapid tranquillisation ‐ needing additional injection during 24 hours · patients with psychosis‐induced aggression or agitation
It is very uncertain whether HALOPERIDOL changes repeated need for rapid tranquillisation ‐ needing additional… compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).
1 finding from 1 review
Specific behaviour ‐ threat or injury to self or others ‐ not reported · patients with psychosis‐induced aggression or agitation
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Global outcome: no overall improvement ‐ at 30 minutes · patients with psychosis‐induced aggression or agitation
It is very uncertain whether HALOPERIDOL changes global outcome: no overall improvement ‐ at 30 minutes compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).
1 finding from 1 review
Adverse effects: specific ‐ dystonia · patients with psychosis‐induced aggression or agitation
It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ dystonia (only reported if occurred in… compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).
1 finding from 1 review
Adverse effects: Specific ‐ hypertonia/rigidity (only reported if occurred in ≥9%) during 24 hours · patients with psychosis‐induced aggression or agitation
It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ hypertonia/rigidity (only reported if… compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).
1 finding from 1 review
Adverse effects: any serious, specific ‐ dystonia during 24 hours · patients with psychosis‐induced aggression or agitation
It is very uncertain whether HALOPERIDOL changes adverse effects: any serious, specific ‐ dystonia during 24 hours compared with OTHER ANTIPSYCHOTIC: a. ARIPIPRAZOLE (very low certainty).
1 finding from 1 review