Question · asked by 1 review
Summary of findings table ‐ Kappa‐opioid agonists vs placebo: Risk for at least one adverse drug reaction (ADR) per participant
- Population
- patients with chronic kidney disease (CKD) pruritus
- Intervention
- Summary of findings table ‐ Kappa‐opioid agonists
- Comparison
- placebo
- Outcome
- Risk for at least one adverse drug reaction (ADR) per participant
Summary of findings table ‐ Kappa‐opioid agonists may leads to higher risk for at least one adverse drug reaction (ADR) per patient compared with placebo (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Risk for at least one adverse drug reaction (ADR) per patient · patients with chronic kidney disease (CKD) pruritus Summary of findings table ‐ Kappa‐opioid agonists may leads to higher risk for at least one adverse drug reaction (ADR) per patient compared with placebo (low certainty). Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane Headline outcomes only | RR 1.73 [1.2, 2.48] | 5 studies · 1344 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.