Lamotrigine vs placebo: 50% or greater reduction in seizure frequency
- Population
- people with drug‐resistant focal epilepsy
- Intervention
- Lamotrigine
- Comparison
- placebo
- Outcome
- 50% or greater reduction in seizure frequency
Summary of findings: lamotrigine probably leads to higher 50% or greater reduction in seizure frequency (ITT analysis) compared with placebo (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Summary of findings: lamotrigine vs placebo 50% or greater reduction in seizure frequency (ITT analysis) · participants with drug‐resistant focal epilepsy Summary of findings: lamotrigine probably leads to higher 50% or greater reduction in seizure frequency (ITT analysis) compared with placebo (moderate certainty). Lamotrigine add‐on therapy for drug‐resistant focal epilepsy (2023) · Cochrane Headline outcomes only | RR 1.8 [1.45, 2.23] | 12 studies · 1322 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Lamotrigine add‐on therapy for drug‐resistant focal epilepsy 2023 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Lamotrigine vs phenobarbital · patients with AD and epileptic seizures · 1 review
- Lamotrigine vs valproate · absence seizures in children and adolescents · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.