IMMEDIATE initiation of cART vs DEFERRED initiation of cART: Proportion of children on ART with HIV‐RNA < 50 copies/ml
IMMEDIATE initiation of cART showed no clear difference in proportion of children on ART with HIV‐RNA < 50 copies/ml (Copy) compared with DEFERRED initiation of cART (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
IMMEDIATE initiation of cART vs DEFERRED initiation of cART Proportion of children on ART with HIV‐RNA < 50 copies/ml (Copy) · HIV‐positive, treatment‐naive children aged one to 12 years old IMMEDIATE initiation of cART showed no clear difference in proportion of children on ART with HIV‐RNA < 50 copies/ml (Copy) compared with DEFERRED initiation of cART (low certainty). Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to… (2013) · Cochrane Headline outcomes only | RR 0.96 [0.84, 1.09] | 2 studies · 238 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to 5 years old 2013 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.