Early ART vs delayed ART initiation: HIV virological suppression at 6 months (viral load < 400 copies/mL)
It is very uncertain whether early ART changes HIV virological suppression at 6 months (viral load < 400 copies/mL) compared with delayed ART initiation (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Early ART vs delayed ART initiation HIV virological suppression at 6 months (viral load < 400 copies/mL) · HIV‐positive people with cryptococcal meningitis It is very uncertain whether early ART changes HIV virological suppression at 6 months (viral load < 400 copies/mL) compared with delayed ART initiation (very low certainty). Early versus delayed antiretroviral treatment in HIV‐positive people with cryptococcal meningitis (2018) · Cochrane Headline outcomes only | RR 0.93 [0.72, 1.22] | 2 studies · 205 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Early versus delayed antiretroviral treatment in HIV‐positive people with cryptococcal meningitis 2018 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.