Summary of findings: Trihexyphenidyl vs placebo: Adverse effectsb (mood disturbance, irritability, behavioural change, constipation) Measured by: counts of number and type
Summary of findings: Trihexyphenidyl may leads to higher adverse effectsb (mood disturbance, irritability, behavioural… compared with placebo (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Summary of findings: Trihexyphenidyl vs placebo Adverse effectsb (mood disturbance, irritability, behavioural change, constipation) Measured by: counts of number and type · children with dystonic cerebral palsy Summary of findings: Trihexyphenidyl may leads to higher adverse effectsb (mood disturbance, irritability, behavioural… compared with placebo (low certainty). Trihexyphenidyl for dystonia in cerebral palsy (2018) · Cochrane Headline outcomes only | RR 2.54 [1.38, 4.67] | 16 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Trihexyphenidyl for dystonia in cerebral palsy 2018 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.