Question · asked by 1 review

Pyridoxal 5 phosphate (vitamin B6) vs placebo: Global: Discontinuation of Vitamin B6

Pyridoxal 5 phosphate (vitamin B6) showed no clear difference in global: Discontinuation of Vitamin B6 compared with placebo (low certainty).

What each review found

Current versions only
FindingEffectStudiesGRADE certainty
Pyridoxal 5 phosphate (vitamin B6) vs Placebo
Global: Discontinuation of Vitamin B6 · patients with neuroleptic‐induced tardive dyskinesia
Pyridoxal 5 phosphate (vitamin B6) showed no clear difference in global: Discontinuation of Vitamin B6 compared with placebo (low certainty).
Pyridoxal 5 phosphate for neuroleptic‐induced tardive dyskinesia (2015) · Cochrane Headline outcomes only
RR 8.72 [0.51, 149.75]2 studies · 65 participantsLow

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Pyridoxal 5 phosphate for neuroleptic‐induced tardive dyskinesia
2015 · Cochrane Headline outcomes only
Not reportedlist not extracted yetNot assessed

Studies behind the findings

None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.

How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.