Inhaled NO vs control: Neurodevelopmental disability
Inhaled NO showed no clear difference in neurodevelopmental disability ‐ Studies with entry after 3 days… compared with control (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Inhaled NO vs control Neurodevelopmental disability ‐ Studies with entry after 3 days based on BPD risk · respiratory failure in preterm infants Inhaled NO showed no clear difference in neurodevelopmental disability ‐ Studies with entry after 3 days… compared with control (moderate certainty). Inhaled nitric oxide for respiratory failure in preterm infants (2017) · Cochrane Headline outcomes only | RR 0.9 [0.74, 1.09] | 2 studies · 498 participants | Moderate |
Inhaled NO vs control Neurodevelopmental disability ‐ Studies of routine use in preterm infants on respiratory support · respiratory failure in preterm infants Inhaled NO showed no clear difference in neurodevelopmental disability ‐ Studies of routine use in preterm… compared with control (high certainty). Inhaled nitric oxide for respiratory failure in preterm infants (2017) · Cochrane Headline outcomes only | RR 0.91 [0.74, 1.13] | 3 studies · 1223 participants | High |
Inhaled NO vs control Neurodevelopmental disability ‐ Studies with entry before 3 days based on oxygenation · respiratory failure in preterm infants Inhaled NO showed no clear difference in neurodevelopmental disability ‐ Studies with entry before 3 days… compared with control (moderate certainty). Inhaled nitric oxide for respiratory failure in preterm infants (2017) · Cochrane Headline outcomes only | RR 1.05 [0.78, 1.4] | 2 studies · 208 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Inhaled nitric oxide for respiratory failure in preterm infants 2017 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.