Moderate-severe active dental caries (exposure) vs Caries-free or mild dental caries (control): TNF-α level
Salivary TNF-α levels are significantly higher in children and young adults with active dental caries than in caries-free or mild-caries controls (SMD 14.81 pg/mL, 95% CI 4.76 to 24.86; 7 studies); ungraded.
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Moderate-severe active dental caries (exposure) vs Caries-free or mild dental caries (control) Salivary TNF-α level (pg/mL) · Children and young adults (3-25 years) · Observational studies in children and young adults across nine countries (saliva-based cytokine comparison) Salivary TNF-α levels are significantly higher in children and young adults with active dental caries than in caries-free or mild-caries controls (SMD 14.81 pg/mL, 95% CI 4.76 to 24.86; 7 studies); ungraded. Activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults with dental caries: a… (2024) All outcomes | SMD 14.81 [4.76, 24.86] | 7 studies · 348 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults with dental caries: a systematic review and… 2024 All outcomes | 15 February 2012 to 13 January 2024 | 15 | Not applicable |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.