PCC vs usual care: All thrombotic events (including myocardial infarction, ischaemic stroke, other arterial thromboembolism, and venous thromboembolism)
PCC showed no clear difference in thrombotic events compared with standard treatment (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
PCC vs standard treatment Thrombotic events · cardiac surgery for the treatment of non‐surgical bleeding PCC showed no clear difference in thrombotic events compared with standard treatment (moderate certainty). Prothrombin complex concentrate in cardiac surgery for the treatment of coagulopathic bleeding (2022) · Cochrane Headline outcomes only | OR 0.68 [0.2, 2.31] | 2 studies · 152 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Prothrombin complex concentrate in cardiac surgery for the treatment of coagulopathic bleeding 2022 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.