Amitriptyline vs placebo: Response rates Number of participants showing a reduction of at least 50% on the Hamilton Depression Rating Scale for Depression, the Montgomery‐Asberg Depression Rating Scale or any other depression scale
Amitriptyline probably leads to higher response to treatment At least 50% reduction of a depression scale… compared with placebo (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Amitriptyline vs placebo Response to treatment At least 50% reduction of a depression scale (mainly Hamilton Depression Rating Scale) · adults with major depressive disorder Amitriptyline probably leads to higher response to treatment At least 50% reduction of a depression scale… compared with placebo (moderate certainty). Amitriptyline versus placebo for major depressive disorder (2012) · Cochrane Headline outcomes only | OR 2.64 [2.28, 3.06] | 31 studies · 3228 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Amitriptyline versus placebo for major depressive disorder 2012 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.