Intravenous diclofenac vs NSAIDs: Number of participants experiencing any serious adverse events
- Population
- Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries
- Intervention
- Intravenous diclofenac
- Comparison
- NSAIDs
- Outcome
- Number of participants experiencing any serious adverse events
Intravenous diclofenac showed no clear difference in number of participants experiencing a serious adverse event compared with another NSAID (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Intravenous diclofenac vs another NSAID Number of participants experiencing a serious adverse event · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or… Intravenous diclofenac showed no clear difference in number of participants experiencing a serious adverse event compared with another NSAID (low certainty). Single‐dose intravenous diclofenac for acute postoperative pain in adults (2018) · Cochrane Headline outcomes only | RR 0.94 [0.13, 6.6] | 4 studies · 423 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Single‐dose intravenous diclofenac for acute postoperative pain in adults 2018 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Intravenous diclofenac vs placebo · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental,… · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.