HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM: Adverse effects: Specific and serious adverse effect ‐ by 24 hours Central nervous system ‐ excessive sedation
- Population
- people with psychosis‐induced aggression
- Intervention
- HALOPERIDOL + PROMETHAZINE
- Comparison
- ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM
- Outcome
- Adverse effects: Specific and serious adverse effect ‐ by 24 hours Central nervous system ‐ excessive sedation
HALOPERIDOL + PROMETHAZINE may leads to lower adverse effects: Specific and serious adverse effect ‐ by 24 hours… compared with ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM Adverse effects: Specific and serious adverse effect ‐ by 24 hours Central nervous system ‐ excessive sedation · people with psychosis‐induced aggression HALOPERIDOL + PROMETHAZINE may leads to lower adverse effects: Specific and serious adverse effect ‐ by 24 hours… compared with ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM (low certainty). Haloperidol plus promethazine for psychosis‐induced aggression (2016) · Cochrane Headline outcomes only | RR 0.12 [0.03, 0.49] | 2 studies · 117 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- HALOPERIDOL + PROMETHAZINE vs OLANZAPINE · people with psychosis‐induced aggression · 1 review
- HALOPERIDOL + PROMETHAZINE vs lorazepam · people with psychosis‐induced aggression · 1 review
- HALOPERIDOL + PROMETHAZINE vs ZIPRASIDONE · people with psychosis‐induced aggression · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.