Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule: Bleeding: Numbers of patients with at least one significant bleeding event
Prophylactic platelet transfusion with one dose schedule showed no clear difference in bleeding Number of participants with a significant bleeding event ‐… compared with prophylactic platelet transfusions with another dose schedule (high certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule Bleeding Number of participants with a significant bleeding event ‐ High dosage platelet transfusions versus standard dosage platelet transfusions · Patients with a haematological disorder Prophylactic platelet transfusion with one dose schedule showed no clear difference in bleeding Number of participants with a significant bleeding event ‐… compared with prophylactic platelet transfusions with another dose schedule (high certainty). Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… (2012) · Cochrane Headline outcomes only | RR 1.02 [0.93, 1.11] | 2 studies · 951 participants | High |
Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule Bleeding: Number of participants with a significant bleeding event ‐ Low dosage platelet transfusions versus standard dosage platelet transfusions · Patients with a haematological disorder Prophylactic platelet transfusion with one dose schedule showed no clear difference in bleeding: Number of participants with a significant bleeding event ‐… compared with prophylactic platelet transfusions with another dose schedule (high certainty). Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… (2012) · Cochrane Headline outcomes only | RR 1.04 [0.95, 1.13] | 3 studies · 1070 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after chemotherapy and stem cell… 2012 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.