Higher‐dose vs lower‐dose nicotine patch: Smoking cessation
Higher‐dose showed no clear difference in smoking cessation ‐ 42/44 mg versus 21/22 mg (24‐hour patches) compared with lower‐dose nicotine patch (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Higher‐dose vs lower‐dose nicotine patch Smoking cessation ‐ 42/44 mg versus 21/22 mg (24‐hour patches) · people who smoke Higher‐dose showed no clear difference in smoking cessation ‐ 42/44 mg versus 21/22 mg (24‐hour patches) compared with lower‐dose nicotine patch (moderate certainty). Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation (2023) · Cochrane Headline outcomes only | RR 1.09 [0.93, 1.29] | 5 studies · 1655 participants | Moderate |
Higher‐dose vs lower‐dose nicotine patch Smoking cessation ‐ 25 mg versus 15 mg (16‐hour patches) · people who smoke Higher‐dose showed no clear difference in smoking cessation ‐ 25 mg versus 15 mg (16‐hour patches) compared with lower‐dose nicotine patch (moderate certainty). Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation (2023) · Cochrane Headline outcomes only | RR 1.19 [1, 1.41] | 3 studies · 3446 participants | Moderate |
Higher‐dose vs lower‐dose nicotine patch Smoking cessation ‐ 21 mg versus 14 mg (24‐hour patches) · people who smoke Higher‐dose probably leads to higher smoking cessation ‐ 21 mg versus 14 mg (24‐hour patches) compared with lower‐dose nicotine patch (moderate certainty). Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation (2023) · Cochrane Headline outcomes only | RR 1.48 [1.06, 2.08] | 1 study · 537 participants | Moderate |
Higher‐dose vs lower‐dose nicotine patch Smoking cessation ‐ 42/44 mg vs 21/22 mg (24‐hour patches) · People who smoke Higher‐dose showed no clear difference in smoking cessation ‐ 42/44 mg vs 21/22 mg (24‐hour patches) compared with lower‐dose nicotine patch (moderate certainty). Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation (2019) · Cochrane Headline outcomes onlyearlier version CD013308, superseded | RR 1.09 [0.93, 1.29] | 5 studies · 1655 participants | Moderate |
Higher‐dose vs lower‐dose nicotine patch Smoking cessation ‐ 25 mg vs 15 mg (16‐hour patches) · People who smoke Higher‐dose showed no clear difference in smoking cessation ‐ 25 mg vs 15 mg (16‐hour patches) compared with lower‐dose nicotine patch (moderate certainty). Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation (2019) · Cochrane Headline outcomes onlyearlier version CD013308, superseded | RR 1.19 [1, 1.41] | 3 studies · 3446 participants | Moderate |
Higher‐dose vs lower‐dose nicotine patch Smoking cessation ‐ 21 mg vs 14 mg (24‐hour patches) · People who smoke Higher‐dose probably leads to higher smoking cessation ‐ 21 mg vs 14 mg (24‐hour patches) compared with lower‐dose nicotine patch (moderate certainty). Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation (2019) · Cochrane Headline outcomes onlyearlier version CD013308, superseded | RR 1.48 [1.06, 2.08] | 1 study · 537 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.