Outer carious dentin (by lesion depth/location) vs Inner carious dentin: MMP-8 location/depth
MMP-8 showed no statistical difference by lesion location; the evidence is very uncertain (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Outer carious dentin (by lesion depth/location) vs Inner carious dentin MMP-8 location/depth · Human ex vivo carious dentin · Ex vivo (extracted teeth / clinical carious or biofilm samples) MMP-8 showed no statistical difference by lesion location; the evidence is very uncertain (very low certainty). Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex… (2023) All outcomes | Mixed: Kuhn 2016 no statistical difference by location; Shimada 2009 higher MMP-8 in outer vs inner carious dentin (very low certainty) | 2 studies | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies. 2023 All outcomes | March 2022 | 18 | Not applicable |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.