Proton pump inhibitors (PPI) vs H2 receptor antagonists (H2RA): Global symptoms of dyspepsia
Proton pump inhibitors (PPI) showed no clear difference in global symptoms of dyspepsia compared with H2 receptor antagonists (H2RA) (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Proton pump inhibitors (PPI) vs H2 receptor antagonists (H2RA) Global symptoms of dyspepsia · adults with functional dyspepsia Proton pump inhibitors (PPI) showed no clear difference in global symptoms of dyspepsia compared with H2 receptor antagonists (H2RA) (low certainty). Proton pump inhibitors for functional dyspepsia (2017) · Cochrane Headline outcomes onlyearlier version CD011194.PUB2, superseded | RR 0.88 [0.74, 1.04] | 2 studies · 740 participants | Low |
Proton pump inhibitors (PPI) vs H2 receptor antagonists (H2RA) Global symptoms of dyspepsia · adults with functional dyspepsia Proton pump inhibitors (PPI) showed no clear difference in global symptoms of dyspepsia compared with H2 receptor antagonists (H2RA) (low certainty). Proton pump inhibitors for functional dyspepsia (2017) · Cochrane Headline outcomes only | RR 0.88 [0.74, 1.04] | 2 studies · 740 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Proton pump inhibitors for functional dyspepsia 2017 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.