Question · asked by 1 review
Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS): Bone mineral density in forearm
- Population
- European-ancestry adults
- Intervention
- Genetically predicted DMFS (dental caries)
- Comparison
- Reference (1-SD lower genetically predicted DMFS)
- Outcome
- Bone mineral density in forearm
Genetically predicted dental caries (DMFS) had no causal effect on forearm BMD.
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Forearm bone mineral density (FA-BMD) · European-ancestry adults · Lifelong genetic liability, European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD), SVMR and MVMR (IVW) Genetically predicted dental caries (DMFS) had no causal effect on forearm BMD. From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) All outcomes | No causal effect of oral diseases on FA-BMD was found (SVMR and MVMR); no numeric estimate reported in text (see Fig. 3). | 8143 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes | Not applicable (secondary analysis of published GWAS summary statistics) | 3 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.