Fluoride-releasing primers/adhesives (Opal Seal; Clearfil Protect Bond) vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control: Enamel demineralization (DIAGNOdent score)
- Population
- Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
- Intervention
- Fluoride-releasing primers/adhesives (Opal Seal; Clearfil Protect Bond)
- Comparison
- Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control
- Outcome
- Enamel demineralization (DIAGNOdent score)
Across three small non-randomized studies, fluoride-releasing primers (Opal Seal, Clearfil) showed no consistent clinical advantage over conventional primers in preventing white spot lesions (ungraded).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Fluoride-releasing primers/adhesives (Opal Seal; Clearfil Protect Bond) vs Conventional primer/adhesive (Transbond XT) White spot lesions / enamel demineralization (photographic scoring, DIAGNOdent, micro-CT) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35) · 8 weeks to full treatment (to debonding), Orthodontic clinical practice (in-vivo human clinical trials); adolescents and adults Across three small non-randomized studies, fluoride-releasing primers (Opal Seal, Clearfil) showed no consistent clinical advantage over conventional primers in preventing white spot lesions (ungraded). Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed… (2024) All outcomes | Three non-randomized studies (Comert 2020 n=56; Oz 2019 n=35; Oz 2017 n=15) showed no consistent clinical advantage. Comert: no significant difference in photographic WSL severity or area, although DIAGNOdent favored… | 3 studies · 106 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic Treatment? A… 2024 All outcomes | October 2023 | 12 | High / Low |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Clinical effect of a fluoride-releasing and rechargeable primer in reducing white spot lesions during orthodontic treatment · 2020 · included by 1 of these review
- Effectiveness of an antibacterial primer used with adhesive-coated brackets on enamel demineralization around brackets: an in vivo study. · 2019 · included by 1 of these review
- In vivo effect of antibacterial and fluoride-releasing adhesives on enamel demineralization around brackets: A micro-CT study. · 2017 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.