Primary study · included by 2 reviews

Clinical effect of a fluoride-releasing and rechargeable primer in reducing white spot lesions during orthodontic treatment

Comert 2020 · Comert Secil, Oz Abdullah Alper · American Journal of Orthodontics and Dentofacial Orthopedics · 2020

doi:10.1016/j.ajodo.2019.06.013journal-article

Trial PICO

Not extracted yet. Trial-level population, intervention, comparator, outcomes and design will appear here after the trial extraction run. Until then, the reviews below describe the study.

Results

Not extracted yet. Per-trial results (events, means, effect and weight as each review's forest plot reports them) will appear here after the trial extraction run.

Included by

Efficacy of sealants and bonding materials during fixed orthodontic treatment to prevent enamel demineralization: a systematic review and meta-analysis.

Non-Cochrane · intervention · 2021 · cited as Comert 2020 · Supplementary Table S3 (included studies); Reference [40]; Fig. 4

Outcome this study informs	Pooled effect	Evidence	Certainty
Initiation of white spot lesions (WSL), visual-tactile assessment Fluoride-releasing glass ionomer-based bonding agent vs Non-fluoride glass ionomer-based bonding agent · 1-24 months follow-up	RR 0.64 [0.41, 0.99]	1 study · 144 participants	Ungraded
Initiation of white spot lesions (WSL), visual-tactile assessment Fluoride-releasing compomer-based bonding agent vs Non-fluoride compomer-based bonding agent · 1-24 months follow-up	RR 0.71 [0.46, 1.11]	2 studies · 400 participants	Ungraded
Initiation of white spot lesions (WSL), visual-tactile assessment Fluoride-releasing resin-based sealant vs Non-fluoride resin-based sealant · 1-24 months follow-up	RR 0.71 [0.35, 1.43]	2 studies · 644 participants	Ungraded
Initiation of white spot lesions (WSL), visual-tactile assessment Coating material (bonding material or sealant) WITH fluoride release vs Coating material WITHOUT fluoride release · 1-24 months follow-up	RR 0.84 [0.70, 1.01]	10 studies · 4705 participants	Very low
Initiation of white spot lesions (WSL), visual-tactile assessment Fluoride-releasing resin-based bonding agent vs Non-fluoride resin-based bonding agent · 1-24 months follow-up	RR 0.97 [0.79, 1.19]	5 studies · 3517 participants	Ungraded

Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic Treatment? A Systematic Review.

Non-Cochrane · intervention · 2024 · cited as Comert et al. 2020 · Table 1 (Comert 2020); Reference 12

Outcome this study informs	Pooled effect	Evidence	Certainty
Photographic white spot lesion severity Opal Seal fluoride-releasing primer vs Conventional Transbond XT primer · During orthodontic treatment	WSL severity in digital photographs: no significant difference between the two groups (p >0.05).	1 study · 56 participants	Ungraded
White spot lesions / enamel demineralization (photographic scoring, DIAGNOdent, micro-CT) Fluoride-releasing primers/adhesives (Opal Seal; Clearfil Protect Bond) vs Conventional primer/adhesive (Transbond XT) · 8 weeks to full treatment (to debonding)	Three non-randomized studies (Comert 2020 n=56; Oz 2019 n=35; Oz 2017 n=15) showed no consistent clinical advantage. Comert: no significant difference in photographic WSL severity or area, although DIAGNOdent favored…	3 studies · 106 participants	Ungraded

2 including reviews in total.