Methadone vs buprenorphine: Use of Primary Substance
Methadone showed no clear difference in use of primary substance compared with buprenorphine (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Methadone vs buprenorphine Use of primary substance · opiate‐dependent pregnant women Methadone showed no clear difference in use of primary substance compared with buprenorphine (low certainty). Maintenance agonist treatments for opiate‐dependent pregnant women (2020) · Cochrane Headline outcomes only | RR 1.81 [0.7, 4.68] | 2 studies · 151 participants | Low |
Methadone vs buprenorphine Use of primary substance Objective · opiate‐dependent pregnant women Methadone showed no clear difference in use of primary substance Objective compared with buprenorphine (low certainty). Maintenance agonist treatments for opiate‐dependent pregnant women (2013) · Cochrane Headline outcomes onlyearlier version CD006318.PUB3, superseded | RR 1.81 [0.7, 4.69] | 2 studies · 151 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.