Cochrane · systematic review · CD006318
Maintenance agonist treatments for opiate‐dependent pregnant women
Minozzi, S, Amato, L, Jahanfar, S, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
12
No studies
1
Included studies
NR
No studies 1 · 7.7%Ungraded 0 · 0%Very low 1 · 7.7%Low 10 · 76.9%Moderate 1 · 7.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyMethadone compared to buprenorphine for opiate‐dependent pregnant women
Population: opiate‐dependent pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dropout rate Methadone vs buprenorphine | RR 0.66 [0.37, 1.2] | 3 studies · 223 participants | Moderate Downgraded: imprecision |
Use of primary substance Methadone vs buprenorphine | RR 1.81 [0.7, 4.68] | 2 studies · 151 participants | Low Downgraded: imprecision |
Birth weight Methadone vs buprenorphine | no estimate extracted | 2 studies · 19 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
APGAR scoreScale from: 0 to 10 Methadone vs buprenorphine | no estimate extracted | 2 studies · 163 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Number treated for NAS Methadone vs buprenorphine | RR 1.19 [0.87, 1.63] | 3 studies · 166 participants | Low Downgraded: imprecision |
Serious adverse events for the mother Methadone vs buprenorphine | RR 1.69 [0.75, 3.83] | 1 study · 175 participants | Low Downgraded: imprecision |
Serious adverse events for the child Methadone vs buprenorphine | RR 4.77 [0.59, 38.49] | 1 study · 131 participants | Low Downgraded: imprecision |
Methadone compared to oral slow‐release morphine for opiate‐dependent pregnant women
Population: opiate‐dependent pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dropout rate from treatment Methadone vs oral slow‐release morphine | no estimate extracted | 1 study · 48 participants | Low |
Use of substance Methadone vs oral slow‐release morphine | RR 2.4 [1, 5.77] | 1 study · 48 participants | Low |
Birth weight Methadone vs oral slow‐release morphine | no estimate extracted | 1 study · 48 participants | Low |
APGAR score (APGAR score ) Methadone vs oral slow‐release morphine | no estimate extracted | NR | No studies |
Adverse events for the mother Methadone vs oral slow‐release morphine | no estimate extracted | 1 study · 48 participants | Low |
Serious adverse events for the child Methadone vs oral slow‐release morphine | no estimate extracted | 1 study · 48 participants | Low |
Methadone compared to buprenorphine for opiate‐dependent pregnant women
Population: opiate‐dependent pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Drop‐out Objective Methadone vs buprenorphine | RR 0.64 [0.41, 1.01] | 3 studies · 223 participants | Low Downgraded: risk of bias, imprecision |
Use of primary substance Objective Methadone vs buprenorphine | RR 1.81 [0.7, 4.69] | 2 studies · 151 participants | Low Downgraded: risk of bias, imprecision |
Birth weight Objective Methadone vs buprenorphine | no estimate extracted | 2 studies · 150 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
APGAR score Objective. Scale from: 0 to 10 Methadone vs buprenorphine | no estimate extracted | 2 studies · 163 participants | Low Downgraded: risk of bias, imprecision |
Number treated for NAS Objective Methadone vs buprenorphine | RR 1.22 [0.89, 1.67] | 3 studies · 166 participants | Very low Downgraded: risk of bias, imprecision |
Methadone compared to oral slow‐release morphine for opiate‐dependent pregnant women
Population: opiate‐dependent pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Use of substance Objective Methadone vs oral slow‐release morphine | RR 2.4 [1, 5.77] | 1 study · 48 participants | Moderate Downgraded: imprecision |
Birth weight Objective Methadone vs oral slow‐release morphine | no estimate extracted | 1 study · 48 participants | Moderate Downgraded: imprecision |