Question · asked by 1 review
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy: Acute necrotising ulcerative periodontitis prevalence
- Population
- Children and adolescents (<18 years) living with HIV (CLWH)
- Intervention
- Combined antiretroviral therapy (cART)
- Comparison
- Monotherapy or dual antiretroviral therapy
- Outcome
- Acute necrotising ulcerative periodontitis prevalence
No significant difference in acute necrotising ulcerative periodontitis between ART regimens (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy Acute necrotising ulcerative periodontitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) · Hospitals and AIDS outpatient centres in India, Brazil, and several Asian countries No significant difference in acute necrotising ulcerative periodontitis between ART regimens (very low certainty). Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) All outcomes | No significant difference in acute necrotising ulcerative periodontitis between CLWH on cART and those on monotherapy or dual therapy (no numeric estimate reported in the text); 1 study(ies). | 1 study | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and Meta-Analysis. 2022 All outcomes | 2022-08-03 (inception to 3 August 2022) | 14 | Critically Low / Low |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.