Acetaminophen plus Diphenhydramine vs placebo: Febrile reactions (fever with or without chills, chills with or without rigors) ‐ Intention‐to treat analysis
Acetaminophen plus Diphenhydramine showed no clear difference in febrile reactions (fever with or without chills, chills with or… compared with placebo (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Acetaminophen plus Diphenhydramine vs placebo Febrile reactions (fever with or without chills, chills with or without rigors) ‐ Intention‐to treat analysis · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions Acetaminophen plus Diphenhydramine showed no clear difference in febrile reactions (fever with or without chills, chills with or… compared with placebo (low certainty). Pharmacological interventions for the prevention of allergic and febrile non‐haemolytic transfusion reactions (2010) · Cochrane Headline outcomes only | RR 0.52 [0.21, 1.25] | 1 study · 334 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Pharmacological interventions for the prevention of allergic and febrile non‐haemolytic transfusion reactions 2010 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.