Question · asked by 1 review

Intervention vs no intervention or control intervention (control): Chronic HCV infection†‐ interferon‐alpha versus no intervention

It is very uncertain whether intervention changes chronic HCV infection†‐ interferon‐alpha versus no intervention compared with no intervention or control intervention (control) (very low certainty).

What each review found

Current versions only
FindingEffectStudiesGRADE certainty
Intervention vs no intervention or control intervention (control)
Chronic HCV infection†‐ interferon‐alpha versus no intervention · people with acute hepatitis C infection
It is very uncertain whether intervention changes chronic HCV infection†‐ interferon‐alpha versus no intervention compared with no intervention or control intervention (control) (very low certainty).
Pharmacological interventions for acute hepatitis C infection (2018) · Cochrane Headline outcomes only
OR 0.27 [0.09, 0.76]3 studies · 99 participantsVery low
Intervention vs no intervention or control intervention (control)
Chronic HCV infection†‐ interferon‐alpha versus no intervention · people with acute hepatitis C infection
It is very uncertain whether intervention changes chronic HCV infection†‐ interferon‐alpha versus no intervention compared with no intervention or control intervention (control) (very low certainty).
Pharmacological interventions for acute hepatitis C infection (2017) · Cochrane Headline outcomes onlyearlier version CD011644.PUB2, superseded
OR 0.27 [0.09, 0.76]3 studies · 99 participantsVery low

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Pharmacological interventions for acute hepatitis C infection
2018 · Cochrane Headline outcomes only
Not reportedlist not extracted yetNot assessed

Studies behind the findings

None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.

How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.