Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline): Development of >=1 new carious lesion (caries incidence)
- Population
- Patients with drooling (sialorrhea) due to neurological disease
- Intervention
- Intraglandular botulinum neurotoxin (BoNT) injection
- Comparison
- No BoNT (placebo or pre-treatment baseline)
- Outcome
- Development of >=1 new carious lesion (caries incidence)
In one RCT, BoNT-B 2500 U was not associated with a statistically significant increase in new caries versus placebo (RR 2.4, 95% CI 0.48 to 11.80; not significant).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline) New dental caries development · Patients with drooling (sialorrhea) due to neurological disease · Neurological-disease populations with drooling (e.g., cerebral palsy, Parkinson disease, adults with sialorrhea); specialist clinical care, BoNT-B 2500 U vs placebo (Isaacson RCT) In one RCT, BoNT-B 2500 U was not associated with a statistically significant increase in new caries versus placebo (RR 2.4, 95% CI 0.48 to 11.80; not significant). Oral health effects of botulinum toxin treatment for drooling: a systematic review. (2020) All outcomes | RR 2.4 [0.48, 11.80] | 1 study | GRADE not reported |
Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline) New dental caries development · Patients with drooling (sialorrhea) due to neurological disease · Neurological-disease populations with drooling (e.g., cerebral palsy, Parkinson disease, adults with sialorrhea); specialist clinical care, BoNT-B 3500 U vs placebo (Isaacson RCT) In one RCT, BoNT-B 3500 U was not associated with a statistically significant increase in new caries versus placebo (RR 1.4, 95% CI 0.24 to 8.12; not significant). Oral health effects of botulinum toxin treatment for drooling: a systematic review. (2020) All outcomes | RR 1.4 [0.24, 8.12] | 1 study | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Oral health effects of botulinum toxin treatment for drooling: a systematic review. 2021 All outcomes | 2019-05 | 8 | Low / Low |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Safety and Efficacy of RimabotulinumtoxinB for Treatment of Sialorrhea in Adults: A Randomized Clinical Trial. · 2020 · included by 1 of these review
- Onabotulinumtoxin A Treatment of Drooling in Children with Cerebral Palsy: A Prospective, Longitudinal Open-Label Study. · 2015 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.