Methotrexate vs placebo: Maintenance of clinical remission
Methotrexate probably leads to higher proportion of patients maintaining clinical remission compared with placebo (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Methotrexate vs placebo Proportion of patients maintaining clinical remission · patients with quiescent Crohn's disease Methotrexate probably leads to higher proportion of patients maintaining clinical remission compared with placebo (moderate certainty). Methotrexate for maintenance of remission in Crohn's disease (2014) · Cochrane Headline outcomes only | RR 1.57 [1.1, 2.23] | 2 studies · 98 participants | Moderate |
Methotrexate vs placebo Proportion of patients maintaining clinical remission (high dose intramuscular methotrexate 15 mg/week) · patients with quiescent Crohn's disease Methotrexate probably leads to higher proportion of patients maintaining clinical remission (high dose… compared with placebo (moderate certainty). Methotrexate for maintenance of remission in Crohn's disease (2014) · Cochrane Headline outcomes only | RR 1.67 [1.05, 2.67] | 1 study · 76 participants | Moderate |
Methotrexate vs placebo Proportion of patients maintaining clinical remission (low dose oral methotrexate 12.5 mg/week) · patients with quiescent Crohn's disease Methotrexate showed no clear difference in proportion of patients maintaining clinical remission (low dose oral… compared with placebo (low certainty). Methotrexate for maintenance of remission in Crohn's disease (2014) · Cochrane Headline outcomes only | RR 1.35 [0.86, 2.12] | 1 study · 22 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Methotrexate for maintenance of remission in Crohn's disease 2014 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.