Metformin vs placebo: Large‐for‐gestational age
- Population
- women with obesity during pregnancy
- Intervention
- Metformin
- Comparison
- placebo
- Outcome
- Large‐for‐gestational age
Metformin showed no clear difference in large‐for‐gestational‐age infant, defined as birthweight ≥ 90th… compared with placebo (high certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Metformin vs placebo Large‐for‐gestational‐age infant, defined as birthweight ≥ 90th percentile for gestational age and infant sex · women with obesity during pregnancy Metformin showed no clear difference in large‐for‐gestational‐age infant, defined as birthweight ≥ 90th… compared with placebo (high certainty). Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes (2018) · Cochrane Headline outcomes only | RR 0.95 [0.7, 1.3] | 2 studies · 831 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes 2018 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Metformin vs glibenclamide ‐ neonatal outcomes · Infants of women diagnosed with gestational diabetes · 1 review
- Metformin vs insulin · women with type 2 diabetes · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.